Could You Be Immune To Everything?

  • Published on Mar 7, 2018
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    Do you remember having a cold in 5th grade? Or the flu a couple years ago? Your immune system does. Our bodies hold many levels of immune defense.Physical barriers like skin, the innate immune system, and our body’s most powerful defender, the adaptive immune system. Millions of B cells and T cells and antibodies are constantly on patrol for germs and antigen invaders. As scientists learn more about how this system works and how to engineer it, could we ever actually be immune to everything?
    Special thanks to Dr. James Crowe (Vanderbilt University)

    Twitter:@DrJoeHanson @okaytobesmart
    Instagram: @DrJoeHanson
    It’s Okay To Be Smart is hosted by Joe Hanson, Ph.D.
    Director: Joe Nicolosi
    Writer: Sarah Keartes
    Creative Director: David Schulte
    Editor/animator: Karl Boettcher and Derek Borsheim
    Producer: Stephanie Noone and Amanda Fox
    Produced by PBS Digital Studios
    Music via APM
    Stock images from Shutterstock

Comments • 839

  • It's Okay To Be Smart
    It's Okay To Be Smart  9 months ago +426

    I've got a fever, and the only prescription is… that you watch this video and share it with your friends and let us know what you think in the comments!

    • Martial Kintu
      Martial Kintu 2 months ago

      I love how you simplified all of this. Thanks a lot . You did a good jobm

    • Mauricio alvarez
      Mauricio alvarez 6 months ago

      Funny, my doctor told me the same thing.🤔

    • ONXONE
      ONXONE 8 months ago


    • Phoenix Uprising
      Phoenix Uprising 8 months ago

      I love your cheesy jokes

    • Lowes Gaming
      Lowes Gaming 8 months ago

      someone already exists like that and its me.

  • Blue Hoodie8
    Blue Hoodie8 2 days ago

    I didnt know vaccines gives our immune system a memory of a bad microorganism so we can be more effective at destroying it.

  • Sorin Doban
    Sorin Doban 6 days ago

    Ew dude i was eating a candy...

  • Obito Uchiha
    Obito Uchiha 9 days ago

    Cells at work .

    *PATENAATTORI 1.0* 16 days ago

    I'm immune for Girlfriend.

  • N00b to Pro Gaming Videos

    Me, being a not-squeamish person: *Sits here watching videos*
    Video: *violently stabs a finger with rose thorn*
    Me: *Makes comment due to how uncomfortable it is making me*

  • Ahmad Najwan
    Ahmad Najwan 20 days ago

    I dont understand a thing lol

  • Daddy AF
    Daddy AF 23 days ago

    Ooooo trans humanism. Gimme!

  • Captain Bork
    Captain Bork 25 days ago

    Response team
    Also goes by AIR team

  • Lowes Gaming
    Lowes Gaming 25 days ago

    I'm already immune to everything .

  • Thieu Quang Trung
    Thieu Quang Trung 28 days ago

    exept HIV viruses i think

  • Pherean Agan
    Pherean Agan 29 days ago

    Nobody is immune to depression

  • Galactic Slayer
    Galactic Slayer 29 days ago

    A moment's silence for all the antibodies, white blood cells and the immune response team. They fought to keep us safe and some lost their lives in the process.

    *trumpet plays*

    NATURAL GAMER Month ago

    Still one day we die.
    Those who born need to die.
    Me or you not even sun or earth.
    All will die one day for good

  • Rushil Jalal
    Rushil Jalal Month ago

    You should have said "Stay Safe"

  • Cheshire Cat
    Cheshire Cat Month ago

    I'm immune to romantic relationships. Don't want or need them anymore and feel a lot better without them

  • Music to the People

    3:48 he said a quintillion is equal to five million trillions, that's wrong. It's a million trillions..

  • Webblz 900
    Webblz 900 Month ago

    Remember kids you can do anything if you put your mind to it. Go be immune to everything fam you got this!

  • manoj varanattu
    manoj varanattu Month ago

    Damn! Even though I didn't understand anything I really enjoyed your video. Thanks 😝

  • Bob Fischer
    Bob Fischer Month ago

    I'll save you the time. The answer is no, you cannot be immune to "everything". If you had a truly pan-immune response, you would also have massive auto-immunity problems. We don't have this because B-cell tolerization occurs during development.

    As far as a pan-influenza antibody goes, that will work for a time, but only as long as influenza A doesn't pick up portions of coat proteins (HA and NA particularly) from other orthomyxoviridae species. The studies they are so casually glossing over do indicate the possibility that having antibodies to antigens from functionally required portions of NA or HA (such that the virus can't mutate them without becoming less infective) could be effective against all infectious influenza A. However, steric blocking mutations would still be possible to lower antibody access while still remaining infective, which one set of authors discusses in the paper. In any case, this whole discussion goes for one family of viruses, influenza A, and not even other RNA viruses, let alone other pathogens that use other means of immune surveillance avoidance (eg, herpes species, spirochete species, etc).

  • Calvin Hodgson
    Calvin Hodgson Month ago

    Quagmire's Tylenol Cold, Flu, & AIDS may soon be a reality.

  • NarendraAIM
    NarendraAIM Month ago

    1:26 that hatted red blood cell. Is it a reference?

  • Korpos Niculina
    Korpos Niculina Month ago

    The less contact you have with other people the less you gonna get sick.

  • IAmDark
    IAmDark Month ago

    I died seeing a cockroach fly

  • kenan Sljivo gaming

    What about allergens when the immune system attacks it self or none threading stuff could you make a video on this.

  • KiRaUsAGiMomo
    KiRaUsAGiMomo Month ago

    So.. If we don’t have vaccines anymore is it possible that a person who has taken those vaccines share their blood with their child to inherit the ability to fight off what the parents have? Just an advanced primitive idea...

  • BM BladeMaster
    BM BladeMaster Month ago

    I am immune to THOTS

  • aidan MacConnell
    aidan MacConnell Month ago

    wait a minute yall dont record the days your sick.... goddamn it

  • Absurdalloy 6
    Absurdalloy 6 Month ago

    Rip to the people who accidentally have only one type of adaptive cell.

  • xTytaa
    xTytaa Month ago

    I wanna be that cell.

    HARDCORE JORO 2 months ago

    Its not ganna happen😞

  • Brielle Cothran
    Brielle Cothran 2 months ago

    Whenever the music stops and he says, "Stay curious." I get chills. 😂

  • Tushar Chowdhury
    Tushar Chowdhury 2 months ago

    Whats kindergarden

  • Fat Coon
    Fat Coon 2 months ago

    Man, my body is a warzone...

  • Eric Taylor
    Eric Taylor 2 months ago

    The only way to be immune to everything is to be dead. If you are dead you can't get sick.
    But even if you were immune to every pathogen on Earth today, something new will evolve tomorrow and that could get you sick.

  • PcMast3Rac3
    PcMast3Rac3 2 months ago

    this channel will be next to Kurzgesagt - In a Nutshell when it comes to illustrated animations..because i will never ever learn just by explanations:)

  • Sasuke Uchiha
    Sasuke Uchiha 2 months ago

    Hataru saibou

  • Itzzben
    Itzzben 2 months ago

    5:40 lol

  • Itzzben
    Itzzben 2 months ago

    WTF Quintle Mutated Antibody

    But it cant theart e bola

  • Downfall
    Downfall 2 months ago

    Humanity certainly cannot be immune to sponsorships and clickbaits, etc.

  • GoldF1shGames
    GoldF1shGames 2 months ago

    Couldn’t immune to my mom rage tho...

  • CloudDayLight
    CloudDayLight 2 months ago

    What's your helper t cell count hmmmmmm

  • Fortnite is fun
    Fortnite is fun 2 months ago +1

    I wish someone would just say the straight answer and liked it so much to the top

  • wcdeich4
    wcdeich4 2 months ago

    I wish our immune systems did not make mistakes thinking things like pollen & animal dander are threats & then remember that :(

  • Kam Wow
    Kam Wow 2 months ago

    Anyone skipped the first part because they watched hataraku saibou

  • Harsh Jadav
    Harsh Jadav 2 months ago +1

    Professor Joe, can you make a video on how plants know something which is threat or beneficial? Like seed spreading animals to plant eating ones. Please and thank you in advance.

  • Harsh Jadav
    Harsh Jadav 2 months ago +1

    Hi professor Joe, you make concept really simple, easy to understand, funny and memorable, and your puns are pretty good too.

  • tetlamed
    tetlamed 2 months ago

    There’s a lot of stretching of the facts here. The gist is quite accurate, but the specifics really aren’t. I’m disappointed

  • Matthew John Vu
    Matthew John Vu 2 months ago

    Makes me feel a lot better about traveling abroad now.

  • Bolverin
    Bolverin 2 months ago

    Antivaxers should see this, great content!

  • Birat Roy
    Birat Roy 2 months ago

    So how cancer kill us?

  • Totally not the flash :3


  • 1400 subs then I leak meh nudes

    Cells at work in a nutshell

  • Allosaur 6
    Allosaur 6 2 months ago

    As an Allosaurus I’m immune to human bs but not parasites.

  • Doughboy
    Doughboy 2 months ago

    I wish I was immune to AIDS

  • Kaan Görmek
    Kaan Görmek 2 months ago

    This video is even better than immune system. İmmune system is fucked up against some certain viruses. İ hate you immune system

  • 1684484448848
    1684484448848 2 months ago

    I got the Ad vaccine it’s called youtube premium

  • Willy Ngaihte
    Willy Ngaihte 2 months ago

    I was born in 2009

  • Blue the velociraptor
    Blue the velociraptor 2 months ago

    Is it just me or does this video make me wanna hurt myself?

  • P Kk
    P Kk 2 months ago

    This video is so cool.

  • Whack 2x
    Whack 2x 2 months ago

    Or your bodies delta force team

  • Cancer Child
    Cancer Child 2 months ago

    I got sneezed on by a 60 year old when watching Shrek 2

  • DaRkNesS
    DaRkNesS 2 months ago

    Tell ur brain to be immune everything

  • kriscross
    kriscross 2 months ago

    Watching this while sick is very ironic..

  • Zepse Wolf
    Zepse Wolf 2 months ago

    A bug that evolve like an antibody but faster and better :0

  • illegal eagle
    illegal eagle 2 months ago

    Virus: you are sick
    "No, you."
    Virus: ack... AAAAAAGAGGHHH!
    "AH, HAHA!"

  • john g
    john g 2 months ago

    Watch cells at work

  • Infinity 58
    Infinity 58 2 months ago

    i know all of this many of your videos dont teach me anything anymore maybe cause ive watched to many of them xD

  • The Edge Boi
    The Edge Boi 2 months ago

    We could be immune to everything besides ligma

  • Minnecraft nguyen
    Minnecraft nguyen 2 months ago +1

    Deadpool saves the day again!

  • The Winspear
    The Winspear 2 months ago +1

    Immune to Death that's what I'm waiting for. But I will die before it's invested.

  • emsh ___
    emsh ___ 2 months ago

    is this the speaker in ted ed?

  • Nishank Patel
    Nishank Patel 2 months ago

    wow. wow. ohh woww... 😳😳😳😳

  • Mr Z
    Mr Z 2 months ago

    I like the animations. I like it so much. So fun to watch 😂

  • ついどろろ
    ついどろろ 2 months ago

    Aggressive white blood cells

  • Rose the Kitty
    Rose the Kitty 2 months ago

    Wowwowoowowowoowowoow such wow

  • Tyler Winchester
    Tyler Winchester 2 months ago

    I think anti-vaxxers are having a stroke at this

  • Daniel
    Daniel 2 months ago

    Great animations! Nice work

  • prahlada Stanley
    prahlada Stanley 2 months ago

    I remembered all those things...

  • Legendary King
    Legendary King 3 months ago +1

    i am immune to ads

  • Deceneu
    Deceneu 3 months ago

    If you understand how antibodies work this videos title and entire premise becomes hilarious. In short NO YOU CAN`T BE IMMUNE TO EVERYTHING and you wouldn`t want to. There is a reason why in most cases the immunity you get from contacting an antigen (vaccine/disease) is temporary and dosen`t last a lifetime. And that reason is receptor + antigen pairing. In essence when an antigen is detected as harmful for your body the immune system will equip certain cells with a receptor capable of detecting said antigen. But that receptor will detect as harmful anything that has the same chain of atoms in the terminal part of the molecule as said antigen meaning the chance of false positives exits. When that false positive immune reaction is provoked by something not harmful you get allergies, when its provoked by another cell in your own body you get autoimmune diseases. Your immune system limits the chance of this happening by limiting the time it considers an antigen dangerous. Make yourself immune to every possible disease all the time and you will make yourself allergic to everything and develop a couple of deadly autoimmune disorders to in the process.

  • NuvYou
    NuvYou 3 months ago

    I haven't been sick in 6-7 years, boosted my immune system using natural substances and feel immune to everything. Your immune system will kill cancer if it's healthy and strong enough so yeah you could be immune to almost everything except the ravages of time and old age.

  • Moin Khan
    Moin Khan 3 months ago

    Superb animations!

  • Random Fatansy
    Random Fatansy 3 months ago

    Hataraku Saibo anime, it's happening in my head instead lol

    • AnduRo
      AnduRo 2 months ago

      Random Fatansy littery

  • Diego Tejada
    Diego Tejada 3 months ago

    I can never prove to myself I'm not immortal

  • Blue Oak
    Blue Oak 3 months ago


  • Olivia Kerr
    Olivia Kerr 3 months ago

    I am ten and I have a cold 😛🤢

  • Talion of Gondor
    Talion of Gondor 3 months ago

    Watch your back Germs, I am Well defended by Silvester Cellone and his Expendable Antibodies

  • LGsus
    LGsus 3 months ago

    last time i got sick was like 2 yrs ago lol

  • Erin Lacey
    Erin Lacey 3 months ago

    Funny animations. Really makes the video more engaging.

  • Mateo Santos
    Mateo Santos 3 months ago

    your guys rock!

  • lf 01
    lf 01 3 months ago

    So what you're saying is that I'm invincible

  • LeKsIdE2
    LeKsIdE2 3 months ago

    Stuff I learned in Immunology class but the animation makes it way easier to understand haha

  • srtm77
    srtm77 3 months ago

    Love the Rocketeer poster at 7:24

  • Ambreen Fatima
    Ambreen Fatima 3 months ago +1

    I feel so safe 💙💙💙

  • RpgBlaster
    RpgBlaster 3 months ago +1

    I never got sick since i was 8 or 9
    now im 18 year old and i'm totally fine
    i guess im special sort of

  • kirtil5
    kirtil5 3 months ago

    they attac
    they protec
    but most importantly
    they never forget

  • TheLegend 27
    TheLegend 27 3 months ago +1

    Yeah you can if Chou didn't get nerfed :(

  • Mr Tony
    Mr Tony 3 months ago +4

    whos been watching Cells at Work?

  • Waltz
    Waltz 3 months ago

    I'm immune to love