Could You Be Immune To Everything?

  • Published on Mar 7, 2018
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    Do you remember having a cold in 5th grade? Or the flu a couple years ago? Your immune system does. Our bodies hold many levels of immune defense.Physical barriers like skin, the innate immune system, and our body’s most powerful defender, the adaptive immune system. Millions of B cells and T cells and antibodies are constantly on patrol for germs and antigen invaders. As scientists learn more about how this system works and how to engineer it, could we ever actually be immune to everything?
    Special thanks to Dr. James Crowe (Vanderbilt University)

    Twitter:@DrJoeHanson @okaytobesmart
    Instagram: @DrJoeHanson
    It’s Okay To Be Smart is hosted by Joe Hanson, Ph.D.
    Director: Joe Nicolosi
    Writer: Sarah Keartes
    Creative Director: David Schulte
    Editor/animator: Karl Boettcher and Derek Borsheim
    Producer: Stephanie Noone and Amanda Fox
    Produced by PBS Digital Studios
    Music via APM
    Stock images from Shutterstock

Comments • 764

  • It's Okay To Be Smart
    It's Okay To Be Smart  6 months ago +389

    I've got a fever, and the only prescription is… that you watch this video and share it with your friends and let us know what you think in the comments!

    • Mauricio alvarez
      Mauricio alvarez 4 months ago

      Funny, my doctor told me the same thing.🤔

    • ONXONE
      ONXONE 5 months ago


    • Phoenix Uprising
      Phoenix Uprising 6 months ago

      I love your cheesy jokes

    • Lowes Gaming
      Lowes Gaming 6 months ago

      someone already exists like that and its me.

    • Aelita Andre
      Aelita Andre 6 months ago

      I’m watching this video to make you better and because I love It’s Ok To Be Smart channel!!!

  • The Winspear
    The Winspear 9 hours ago +1

    Immune to Death that's what I'm waiting for. But I will die before it's invested.

  • emsh ___
    emsh ___ 2 days ago

    is this the speaker in ted ed?

  • Nishank Patel
    Nishank Patel 4 days ago

    wow. wow. ohh woww... 😳😳😳😳

  • Mr Z
    Mr Z 4 days ago

    I like the animations. I like it so much. So fun to watch 😂

  • ついどろろ
    ついどろろ 5 days ago

    Aggressive white blood cells

  • That fox In a meadow

    Wowwowoowowowoowowoow such wow

  • Louis Ben-Joseph
    Louis Ben-Joseph 6 days ago

    I think anti-vaxxers are having a stroke at this

  • Daniel
    Daniel 8 days ago

    Great animations! Nice work

  • prahlada Stanley
    prahlada Stanley 8 days ago

    I remembered all those things...

  • Legendary King
    Legendary King 9 days ago +1

    i am immune to ads

  • Deceneu
    Deceneu 9 days ago

    If you understand how antibodies work this videos title and entire premise becomes hilarious. In short NO YOU CAN`T BE IMMUNE TO EVERYTHING and you wouldn`t want to. There is a reason why in most cases the immunity you get from contacting an antigen (vaccine/disease) is temporary and dosen`t last a lifetime. And that reason is receptor + antigen pairing. In essence when an antigen is detected as harmful for your body the immune system will equip certain cells with a receptor capable of detecting said antigen. But that receptor will detect as harmful anything that has the same chain of atoms in the terminal part of the molecule as said antigen meaning the chance of false positives exits. When that false positive immune reaction is provoked by something not harmful you get allergies, when its provoked by another cell in your own body you get autoimmune diseases. Your immune system limits the chance of this happening by limiting the time it considers an antigen dangerous. Make yourself immune to every possible disease all the time and you will make yourself allergic to everything and develop a couple of deadly autoimmune disorders to in the process.

  • NuvYou
    NuvYou 10 days ago

    I haven't been sick in 6-7 years, boosted my immune system using natural substances and feel immune to everything. Your immune system will kill cancer if it's healthy and strong enough so yeah you could be immune to almost everything except the ravages of time and old age.

  • Moin Khan
    Moin Khan 12 days ago

    Superb animations!

  • Random Fatansy
    Random Fatansy 14 days ago

    Hataraku Saibo anime, it's happening in my head instead lol

    • AnduRo
      AnduRo 5 days ago

      Random Fatansy littery

  • Diego Tejada
    Diego Tejada 14 days ago

    I can never prove to myself I'm not immortal

  • Blue Oak
    Blue Oak 15 days ago


  • Olivia Kerr
    Olivia Kerr 16 days ago

    I am ten and I have a cold 😛🤢

  • Talion of Gondor
    Talion of Gondor 17 days ago

    Watch your back Germs, I am Well defended by Silvester Cellone and his Expendable Antibodies

  • LGsus
    LGsus 18 days ago

    last time i got sick was like 2 yrs ago lol

  • Erin Lacey
    Erin Lacey 20 days ago

    Funny animations. Really makes the video more engaging.

  • Mateo Santos
    Mateo Santos 21 day ago

    your guys rock!

  • lf 01
    lf 01 21 day ago

    So what you're saying is that I'm invincible

  • LeKsIdE2
    LeKsIdE2 25 days ago

    Stuff I learned in Immunology class but the animation makes it way easier to understand haha

  • srtm77
    srtm77 25 days ago

    Love the Rocketeer poster at 7:24

  • Ambreen Fatima
    Ambreen Fatima 26 days ago +1

    I feel so safe 💙💙💙

  • RpgBlaster Rpg
    RpgBlaster Rpg 27 days ago +1

    I never got sick since i was 8 or 9
    now im 18 year old and i'm totally fine
    i guess im special sort of

  • kirtil5
    kirtil5 Month ago

    they attac
    they protec
    but most importantly
    they never forget

  • Mariah
    Mariah Month ago

    Im 19 and I never get sick anymore. I havent had a cold since I was in middle school. One time I went swimming in a cold lake and I had a fever for a whole day, but I wouldnt say I was sick. I get a stuffy nose here or there, but i never get a full blown cold. I think im immune to everything.

  • TheLegend 27
    TheLegend 27 Month ago +1

    Yeah you can if Chou didn't get nerfed :(

  • Mr Tony
    Mr Tony Month ago +2

    whos been watching Cells at Work?

  • Waltz
    Waltz Month ago

    I'm immune to love

  • I would like to remain anonymous

    I wish that the video had elaborated more on the topic of the allways working antibodies that could help us become immune to anything and then everything. How do they work? How would we get them into ourself/how would we make them ourself? Will it only work for viral disseases or also bacterial? Is there any risk involved in it?
    The video also glanced over the fact that the spanish flu came back in 2009! The most deadly disease in recent history came back? I necer heard of that! Could it be so that the spanish flu is the older strain of the swine flu? Because the swine flu ”epidemic” was around that time of 2009. I don’t really remember since I was a little kid back then.
    Overall, great topic with much needed infomeration for those who don’t know how the immune system works, but the pace if the video was waaay to fast! I want to know more about the possibility to cure all infectious diseases!

  • Stijn S.
    Stijn S. Month ago +1

    I thought the antibodies were eggs lol

  • Kuro Bombs
    Kuro Bombs Month ago

    I'm immune to living. *wait*

  • ayoosh iyer
    ayoosh iyer Month ago

    Look at that star at bottom left 2:45

  • TechJunkie
    TechJunkie Month ago

    Quagmire is immune to all diseases.

  • Pundit Man
    Pundit Man Month ago

    See: Cells at Work for realistic documentary.

  • samurifish197
    samurifish197 Month ago

    for any extra information please refer to "Cells at Work"
    it is a wonderful and scientifically accurate representation of what is happening inside your body

  • Maddox Martin
    Maddox Martin Month ago +1

    My dad works for Mr. Hendrics the founder of curiosity stream.

  • Skylights
    Skylights Month ago

    i want to be immune to depression

  • Dylan Lopez
    Dylan Lopez Month ago

    There's another video almost the same as this one,

  • Immortal SoFar
    Immortal SoFar Month ago

    Bad news. As a long-term allergy sufferer, I have become increasingly convinced that the cause of allergies is that the one thing evolution has never had to deal with is a bored immune system. When there's no real threat, it attacks whatever comes to hand - even your own body.
    Try it, allergy sufferers - eat more dirt (metaphorically) and see what having a real threat does to your allergies. If this is true, then a supercharged immune system with nothing to do would probably be fatal.

  • Misses Witch
    Misses Witch Month ago

    Wait, Chemical weapons?! That's against the Geneva convention!

  • Bekim Qaili
    Bekim Qaili Month ago

    No still allergic to stupid people. 😝

  • ʜᴀsᴛᴜʀ σмєи

    I don't think it's possible to ever truly be immune to all diseases and germs.

  • chanaW
    chanaW 2 months ago

    I thought antibody is just a protein that float around in our blood stream not sticking its tail to the cell membrane, not even B cells, except for IgM which attach to the mast cells??? Correct me if I am incorrect

    ISHAN SHETTY 2 months ago

    Would it ever be possible to be immune to AIDS? ,because I read somewhere that the virus is highly mutagenic, so it doesn't have any one pattern to lock on to.
    By the way, the team simply nailed the animations this time, SHEER PERFECTION.

  • Spartan 1347
    Spartan 1347 2 months ago

    I watched virus that kills other bacteria

  • Raspberry Fury
    Raspberry Fury 2 months ago +2

    dont lewd the platelet loli

  • Louis Thomas
    Louis Thomas 2 months ago

    did you really reference Speed 2: Cruise Control? you need to be shot

  • JLknight Etherion
    JLknight Etherion 2 months ago

    How about Phages?

  • V.ChiLL 79
    V.ChiLL 79 2 months ago

    That's why it's good to be exposed to germs, instead of White People trying to be so germ free, pussys

  • Felhek Lehrian
    Felhek Lehrian 2 months ago

    But even if rhinovirus or cold virus is always changing.
    Even if that's the case, how many "abilities " could they have?
    There Must be a limit.
    They all give you the same symptoms.
    Just create something to protect the "things" vulnerable to produce those symptoms!!
    Can't be that hard to do.
    Just do it!!.
    No matter how many mutations, they always cause the same symptoms.

      ISHAN SHETTY 2 months ago

      Felhek Lehrian Well, viruses are somewhat of a living paradox I.e there is a debate on whether they can be said to be living.This is because viruses are non-living outside and as they come in contact with a host they suddenly capture over the host's mechanism and BAM! you get an infection. So if the viruses are not living outside its impossible for them to have predators, right?. Hope I am clear enough.

    • Felhek Lehrian
      Felhek Lehrian 2 months ago

      ISHAN SHETTY True but, how many combination these "locks" could have?
      It is interesting to learn more about those viruses.
      We could use their perfect lock system and adapt them to our real locks.
      Imagine a computer with such behavior. An always changing lock.
      But in nature there are always predators.
      Do viruses have natural predators?
      Do they eat them?

      ISHAN SHETTY 2 months ago

      Felhek Lehrian Antibodies have a particular pattern for every particular antigen (which are the foreign bodies), so instead of seeing antibodies as gloves which change according to the antigen, visualise them as locks and keys where the antibodies are the locks and only particular antigen make the key. So what you say might be correct that some part may always remain the same but the fact remains that even slight changes will make the antibody to not recognize the antigen.

    • Felhek Lehrian
      Felhek Lehrian 2 months ago

      ISHAN SHETTY yes but there must be something that always stays the same, something that never mutates.
      If not, how do you know the difference from 1 virus to another?
      The shape? Behavior?
      If you draw a circle by hand, every time you draw a new one, it'll be different than the last one.
      But you still can identify it as a circle.

      ISHAN SHETTY 2 months ago +2

      The problem isn't that they are changing, the difficulty lies in the fact that there are hundreds of strains of the virus causing the flu, and every season a new variety freshly mutated arrives. At present,it simply isn't both feasible and logical to develop so many vaccines for a virus that has minimal chances of being threatening.

  • megan allen
    megan allen 2 months ago

    A whole lot of people think that your able to get sick from a vaccine,but it is completely impossible,because they use a confirmed DEAD version of it

  • danielwoods1591
    danielwoods1591 2 months ago

    Heh heh, The AIR Team, the best cell for the worst germs XD

  • VOID
    VOID 2 months ago

    Ya but the reason you still get a cold next year is because that cold has mutated and your body doesn’t have immunity to it

  • Nova 21303
    Nova 21303 2 months ago

    How to become invincible:
    Find the universe developer console
    Type in sv_cheats 1
    Type in god
    The universe was modeled after the source engine

  • Super Strange Planet
    Super Strange Planet 2 months ago

    Me:) immune to ads on this vid

  • captainrobots
    captainrobots 2 months ago

    The only sickness is from eating food my body isnt used to but not allergic to or just have stomach problem when I travel to a new place for about a hour. But never been staying at home sick in bed.

  • Arthur Extreme
    Arthur Extreme 2 months ago

    Illegal imvasion in private places: calls the police and it send it to jail
    Illegal invasion in your body: DROP TOXIC IN IT AND EAT ITS FLESH

  • Sophia Stortti
    Sophia Stortti 2 months ago


  • Lê Sathie
    Lê Sathie 2 months ago

    Things start become bad whem you desenvolv a self imune disease... and all system get crazy and start attack healty organs for example...

  • Rj Pena
    Rj Pena 2 months ago

    Okay but Why dosent the body remeber the rabies vaccine forever?

  • Rollu Kauppa
    Rollu Kauppa 2 months ago

    being immune to a vacuum space is impossible

  • CookieDonutMonster
    CookieDonutMonster 2 months ago

    I’m immune to fandoms

  • Unknown.
    Unknown. 2 months ago

    This is my first comment i'm from egypt and I'd like to say that i like watching your videos as i benefit much from them. thanks a lot for your great videos.

  • Salted Sea
    Salted Sea 2 months ago

    im immune of getting dark or getting sunburn

  • iDrakeZz ِ
    iDrakeZz ِ 3 months ago

    well if u got sick enough

  • Delete Me
    Delete Me 3 months ago


  • vishal raj
    vishal raj 3 months ago

    How did immune system evolve?

  • Matthew Martel
    Matthew Martel 3 months ago +1

    I'm disappointed. There was no clever pun at the end of the video...

  • Game Reaction
    Game Reaction 3 months ago +1

    l have not gotten cold for 3 years 🤔🤔

  • Alexandru Bucur Dan
    Alexandru Bucur Dan 3 months ago

    Nice animation i love them :)

  • Non Ridiculous Adjective

    White blood cell: You're not Garry

  • David  Lucey
    David Lucey 3 months ago

    I hate to say it, but I’m not too impressed with the immune system. Case in point Black Death and AIDS

  • De Boi Biko
    De Boi Biko 3 months ago

    But then youre not immune to being not immune...

  • GinkaV
    GinkaV 3 months ago

    I work in Immunohistochemistry, I remember when I learned about it, I was static for a few days. Please talk about it! #question

  • patryn36
    patryn36 3 months ago

    they forgot or deliberately choose not to mention the main reason why one may or may noy get affected by a virus. a virus can only affect one if they have the protein receptor needed by the virus. bacteria just need favorable conditions.

  • Aldrin Miles Partosa
    Aldrin Miles Partosa 3 months ago

    Like the vid

  • Indie Development Labs
    Indie Development Labs 3 months ago

    What if trying to be immune to everything makes the germs and viruses adapt to all our immune system has to offer leading to many deaths?

  • Retro Electro
    Retro Electro 4 months ago

    What if antibodies were unspeacilised?

  • Mr. Monster
    Mr. Monster 4 months ago

    But you can't be immune to bullshit

  • xXFox101Xx ;
    xXFox101Xx ; 4 months ago

    I'm watching this and I think I'm sick

  • Champawsome
    Champawsome 4 months ago

    whn your sick

  • Silver Bronze
    Silver Bronze 4 months ago

    Could would be immune to anything? Aren’t we already immune to a lot of things?

  • Lily Hults
    Lily Hults 4 months ago

    I love animation in this video

  • ColtaineCrows
    ColtaineCrows 4 months ago

    I feel like I'm pretty much immune to everything already. I don't really get sick. Well, I get colds occasionally, but I don't really feel like that counts as being sick.

  • Mirrored {} Chaos
    Mirrored {} Chaos 4 months ago

    some guy on outragious acts of science gets bit by his snake everyday, he builds an immunity towards the venom to the point were a full on bite doesnt affect him. we should do something like that to more serious things that kill people everyday, just enough exposure to not kill you and so your immune system can make enough antibodies to fight it off. maybe this can benifit us in some way idk.

  • Steven Cherry
    Steven Cherry 4 months ago

    Why couldn't you also just take blood donations from a huge pile of people, mix it and give a whole lot of people a few drops of a variety of those b cells?

  • life is great with kool-aid

    Humans get killed everyday by microscopic circles, how can we ever hope to be to immune to anything, lol.

  • Gottkönig
    Gottkönig 4 months ago

    Everytime when it´s fluseason most of the people around me get it but I never got it in 22 Years of my Life. sometimes i get a bronchitis of it, what last for a weak when i go to work or school, when i stay home its gone after 2 days xD expect of that i never get sick :D Ok i get a running nose in winter, but that is more of the climate in Germany i think. And now hold on: I didn´t vaccinate since Ten Years or so, is that a God-like immunesystem or not? :D

  • Chloe Watson
    Chloe Watson 4 months ago

    Am I the only person to never have gotten a flu shot and to only have gotten the flu once?

    PREPFORIT 4 months ago

    I want Rare Antibodies NOW ! ( checks amazon ) DAM !

    WIFIGHOST CRUISER 4 months ago

    I guess not, after watching this video I found out I wasn't immune to boredom.

  • scott hough
    scott hough 4 months ago

    Your body cant hold that many antibody shapes but a computer could if you programed it to store them and come up with them.

  • Ryan yuan
    Ryan yuan 4 months ago

    In a helicopter and random blood cells float ABOVE by like a mile.

  • James Deininger
    James Deininger 4 months ago

    Speed 2: Cruise Control!! Sandra Bullock probably doesn’t even remember it. I bet half your audience wasn’t even born yet 😂😂😂

  • Shane Scott
    Shane Scott 4 months ago

    About a quarter of people in my area are immune to Hepatitis C, there are even people immune to HIV, I live in South Africa, and I've come across this. Very rare, but yes.

  • Dragon GamerGirl
    Dragon GamerGirl 4 months ago

    I wish we started using these videos in class.