Could You Be Immune To Everything?

  • Published on Mar 7, 2018
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    Do you remember having a cold in 5th grade? Or the flu a couple years ago? Your immune system does. Our bodies hold many levels of immune defense.Physical barriers like skin, the innate immune system, and our body’s most powerful defender, the adaptive immune system. Millions of B cells and T cells and antibodies are constantly on patrol for germs and antigen invaders. As scientists learn more about how this system works and how to engineer it, could we ever actually be immune to everything?
    Special thanks to Dr. James Crowe (Vanderbilt University)

    Twitter:@DrJoeHanson @okaytobesmart
    Instagram: @DrJoeHanson
    It’s Okay To Be Smart is hosted by Joe Hanson, Ph.D.
    Director: Joe Nicolosi
    Writer: Sarah Keartes
    Creative Director: David Schulte
    Editor/animator: Karl Boettcher and Derek Borsheim
    Producer: Stephanie Noone and Amanda Fox
    Produced by PBS Digital Studios
    Music via APM
    Stock images from Shutterstock

Comments • 743

  • It's Okay To Be Smart
    It's Okay To Be Smart  16 days ago +297

    I've got a fever, and the only prescription is… that you watch this video and share it with your friends and let us know what you think in the comments!

    • Kelly Le
      Kelly Le 3 days ago

      I love your cheesy jokes

    • Delmaine Lowe
      Delmaine Lowe 3 days ago

      someone already exists like that and its me.

    • Aelita Andre
      Aelita Andre 13 days ago

      I’m watching this video to make you better and because I love It’s Ok To Be Smart channel!!!

    • Kai Yan
      Kai Yan 14 days ago

      It's Okay To Be Smart I have a test about the immune system in 2 weeks, great thanks

  • Alex McCabe
    Alex McCabe Day ago

    mind blown

  • SSmpGaming
    SSmpGaming 2 days ago

    F U L L M E T A L B L O O D C E L L

  • Landon Stelwagen
    Landon Stelwagen 3 days ago

    I liked the Rocketeer Poster

  • lim sin
    lim sin 3 days ago

    This is for ask joe anything but how did blue eyes come about

  • RaVen McCraig
    RaVen McCraig 3 days ago

    You're videos are so cool. You're narration and the video animatioms make Science more fun.

  • George Carpenter
    George Carpenter 3 days ago

    I never get sick, not even the flu, never had a flu shot either.

  • Patrik Rasch
    Patrik Rasch 4 days ago

    The animation and editing in this video is so incredibly well done!

  • Arah - nya
    Arah - nya 4 days ago

    I don't like that smart ass way of saying stay curious.

  • Timwi Heizmann
    Timwi Heizmann 4 days ago

    I would love to see a video on the Mpemba effect.

  • codeman7055
    codeman7055 5 days ago

    I already know I'm immune to anything that is consumable and dangerous. Can't count how many times I've overdosed and yet I'm still here yay me.

  • Cutie Pie
    Cutie Pie 5 days ago

    My immune system is USELESS!! I've always gotten sick a lot since I was little, I feel like my immune system is lazy -.-

  • Monotheistic Person
    Monotheistic Person 5 days ago

    Wanna immunity to all diseases?
    Put Esuna in your blood stream.

  • Captain Hindsight
    Captain Hindsight 5 days ago

    Binary Fusion

  • Captain Hindsight
    Captain Hindsight 5 days ago

    Impossible to be immune to everything, because there is to much everything...

  • Fadhel Alyunis
    Fadhel Alyunis 5 days ago

    Why do we cry?

  • Cadence Mornile
    Cadence Mornile 5 days ago

    Je me sens rivière!

  • nirmites _TheGamers
    nirmites _TheGamers 6 days ago +1

    I am nirmites...

  • Vely Chazaro
    Vely Chazaro 6 days ago

    Havnt got notifications from you in like 3 months, cool. I had to search your channel cuz i was wondering if you really hadnt uploaded

  • Holy Keyblade
    Holy Keyblade 6 days ago

    My immune system is swelling up my throat right now

  • 19billdong96
    19billdong96 7 days ago

    How does resistance to poison work? How does introducing micro doses repeatedly create resistance? Would love to learn!

  • Alex Thompson
    Alex Thompson 8 days ago

    I'd be super interested in an animated video like this about autoimmune issues/diseases.

  • Ergo Nomic
    Ergo Nomic 8 days ago

    Sadly there is no money to medicine business if everybody will stay healthy :/

  • workinghoustonian
    workinghoustonian 9 days ago

    Colds, problem....however i was not and still am not immune to Speed2 :(

  • Марибел Кръстева

    Please do a tribute to Stephen Hawking and his work as he sadly passed away this morning 😔 R.I.P.

  • Stavri Stavrev
    Stavri Stavrev 9 days ago

    Hi, great channel, love the content. So a while ago you made a clip about plants, and if they can feel. In the end you said plants don't react to music, but i watched a documentary on water and how music changes the structure of the water molecule, and since plants as well as humans are made of so much water, music actually affects both us and the plants. And this shows in the way the plant grows or in the mood swings we have. Is that true and if so can you do some kind of explanation about how this is possible. I think the documentary is called "Water: The great mystery"

  • Dontbea Hero
    Dontbea Hero 9 days ago

    Im immune to reptillian death rays

  • Sumitra Nehra
    Sumitra Nehra 9 days ago

    I have a question but it is not related to this topic
    Can we increase the height to which we can suck water through straw by making the base diameter of straw larger
    I mean that if we make a straw that base diameter is larger then top diameter then can we increase the height to which the water can be sucked

  • That_one Alcoholic
    That_one Alcoholic 9 days ago

    Pls help I can’t get sick

  • Saul M.
    Saul M. 9 days ago

    Is the reason that we still get colds because its a different virus each time?

  • xtreme494
    xtreme494 10 days ago

    nice animation :D

  • Joshua Salomon
    Joshua Salomon 10 days ago

    Could I download my consciousness into a robot, if yes then you could be immune to every disease except for a computer virus but that doesn't count

  • Alois Mahdal
    Alois Mahdal 11 days ago

    4:27 wtf is that a box of Lucky Strikes?

  • TheCstar07
    TheCstar07 11 days ago

    The Animation just elevates this video. Fun and Informative, great video!

  • Ryan Mackay
    Ryan Mackay 11 days ago

    How is quagmire then?

  • The Exoplanets Channel
    The Exoplanets Channel 11 days ago +10

    *i wish there were no diseases on Earth*

    • Captain Hindsight
      Captain Hindsight 5 days ago +2

      They are bad, but having them allows us to make advancements in science.
      If an alien bacteria came from space, we will be more prepared because of them.

  • Adam Naji
    Adam Naji 11 days ago +1

    Hey guys, I made a science video about Newton's canon for a contest and I was wondering if you could give it a thumb up, please show some support😘

  • William Parker
    William Parker 12 days ago

    Very interesting...

  • Justin Chang
    Justin Chang 12 days ago

    I just hope that I am immune to studying.

  • Bỉnh Thanh Le
    Bỉnh Thanh Le 12 days ago

    I love the new animation!!!!

  • Eugene Donovan
    Eugene Donovan 12 days ago

    quality lean column personally child release.

  • Jonny eh
    Jonny eh 12 days ago

    The Spanish flu returned?!

  • oscar Masuku
    oscar Masuku 12 days ago

    It’s funny cause I’m learning about the immune system in health class

  • Quinnard1234
    Quinnard1234 12 days ago

    What if we had two brains? And two hearts?

  • Gavin Reed
    Gavin Reed 12 days ago

    The only one who can do that is Kars.

  • Gamer2002
    Gamer2002 12 days ago

    Very good video!!

  • Rowan Watts
    Rowan Watts 12 days ago

    that's why we get sick less as we get older

  • Reigyn
    Reigyn 12 days ago

    Never knew how impressive and cool this topic is. Your way of explaining things only makes it better! ^^

  • elizabeth davis
    elizabeth davis 12 days ago

    Do a video on how indigineous people populated north and south america

  • pioneer foundation
    pioneer foundation 13 days ago +1

    Sir iam always amazed at one thing that why cow 🐮 eat's grass
    What causes this natural tendency sir please make a video on it in fact it's logical

  • Julie Jepsen
    Julie Jepsen 13 days ago

    Question: If you kiss a person with immunity, could your body get the same immunity without ever being in contact with the particular virus?

  • Derpster
    Derpster 13 days ago

    Best animation ever.

  • Het _life
    Het _life 13 days ago

    I just found this Instagram account named "robots_will_us" wtf

    BOSS VJ BEAST 13 days ago

    And since we are more bactiria then " human" who is our immune system protecting?

    BOSS VJ BEAST 13 days ago

    Watching this while having the sniffles and a wheezing cough i wish i was immune to all already

  • DaniCaliLA
    DaniCaliLA 13 days ago

    And ur honestly going to tell me there is no god😒

  • Galaxis
    Galaxis 13 days ago

    There has to be a cost though. Like, if you have antibodies to 1000 things, for them to be effective, don't they have to be quite numerous in your body? Something has to be there where the virus or whatever is if it's going to detect it. So, with all that running around, is your adaptive portion of your immune system weaker? I mean, you can only have just so many immunity cells running around in your blood, right?

  • Spooferish
    Spooferish 13 days ago

    Information was good but animations were great and fun to watch.

  • sachin kumar
    sachin kumar 13 days ago

    # It's Okay To Be Smart. JOE if same charge repel each other. so how in atoms nuclesus all protons can stick with each other??????

  • TypicalEgg
    TypicalEgg 13 days ago

    Mitochondria is the powerhouse of the cell

  • 42x3
    42x3 13 days ago

    Aww.. cute for a basic understanding of virus to immune system response. If genetically we were the same, universal jabs would work. Unfortunately, your responses to a virus are based on how healthy your system was working in the first place and who your parents were and who their parents were all the back to the mitochondrial eve. You may have heard the terms genetically susceptible to a virus or a disease.
    Let’s use allergies as an example of a foreign body invasion. For some, a Bee Sting can be fatal and for others it will not be. When the venom enters the body, the body reacts and for those allergic, it means your body cannot handle the venom. It does not know how to deal with the bee’s venom correctly. However, the body can potentially learn the defense, but it can take from one more sting to an infinite amount for the body to catch on. You can see this in people who “grow” out of an allergy either by lessening or completely.
    The same thing happens with viral illness. You may be quick to fight it off, or you may forever fail because your body cannot cope.
    There a several virus in the world ranging from HSV-1 (which almost 50% of the population has) all the way to and beyond AITD. It is impossible for the body to fight these viruses without outside assistance.
    Now regarding a “universal” one shot deal. I am thinking if it ever happens, the cost would be limited to those will substantial funds. As it would put pharmaceutical companies out of business. As a point of reference, in 2014 a treatment for someone with HEB-C cost $84,000 for a 12 week supply. Imagine if it doesn’t work and you have to do it again. Gesh.
    The best course of action is to keep your body physically strong (good food, and all that blah blah that we all know we should be doing)
    Plus be vaccinated for everything we possibly can. Not just for yourself, but for the herd effect.
    Anyway, that’s my thoughts. 😂

  • aluf mangoes
    aluf mangoes 13 days ago

    can you be immune to breakups?

  • meareAaron
    meareAaron 13 days ago

    Really love those animations hahaha pretty funny i terpretation hahaha

  • PepperGames
    PepperGames 13 days ago

    You can't be immune to her lies

  • Soup Gaming
    Soup Gaming 13 days ago

    You make this sound like we are immune but I don’t think so

  • Денис Жилов
    Денис Жилов 13 days ago

    Lift mark interesting depend legislative trail could suburb student hold.

  • Steeve
    Steeve 13 days ago

    That was a fantastic introduction to the immune system

  • Gamer Fluff27
    Gamer Fluff27 13 days ago

    I got a cold :(

  • Eli Cuevas
    Eli Cuevas 13 days ago

    thank you joe phd. reminds me of watching pbs as a kid

  • John Edward Jones
    John Edward Jones 13 days ago

    I have a very smart MD.Referred to as a doctor's doctor. I had a check-in a few weeks ago. For more than a decade she has insisted that I get various 'shots'...We were talking about the flu epidemic going on and the utter stupidity of not getting a flu shot each year. Although it may only be 12% to 60% in any given year those there is a cumulative positive effect. Those that have been getting the vaccine over many years have much less risk of catching the flu. Significantly lower risk.

  • Cloning Phantom
    Cloning Phantom 13 days ago +1

    So many info channels get on trending

  • Simply Terrell
    Simply Terrell 13 days ago

    Am I smart enough to get 10 subs no okay

  • Gidaio
    Gidaio 13 days ago

    The animation in this episode was brilliant!

  • Manny G
    Manny G 13 days ago

    I love this channel make me feel smart lol

  • Fox Smith
    Fox Smith 14 days ago +1

    So theoretically we have to make the human body large enough to hold all the different type of antibodies or create one antibody that can adapt to any invader?

  • D Hawthorne
    D Hawthorne 14 days ago

    O.O Speed II? I remember watching that when I was about 12. My dad had it recording so I couldn't change the channel.

  • Max Harrison
    Max Harrison 14 days ago

    Videos about allergies, especially peanut allergies and anaphylactic reactions PLEASE.

  • Zynax
    Zynax 14 days ago

    Holy moly, we're that complex? I mean look, 1:27 that is a red cell with a HAT!

  • TuckFheIlluminati
    TuckFheIlluminati 14 days ago

    but you wouldn't be immune of being immune

  • Dexter Wilkinson
    Dexter Wilkinson 14 days ago

    potentially home enough dream private adolescent.

    SAGIN ANIL 14 days ago +1

    Pls make a video of all the names of large numbers... Give a like if u agree viewers...

  • Vartholomeos to provato Tv

    Yeah but then you wouldn't be immune to immunity .

  • kanibar15
    kanibar15 14 days ago

    I about lost it when the adaptive immune system cells shot the virus 😂

  • suf sanin
    suf sanin 14 days ago +1

    That's why you should not wash your hands TOO often if you wan a devoloped immune system

  • Ski_doo
    Ski_doo 14 days ago

    Is it just me Or at 215 those are eggs

  • I Love Creativity
    I Love Creativity 14 days ago

    Some of the animations in this video remind me of Courage the Cowardly Dog show.

  • Limit Breaker Goku
    Limit Breaker Goku 14 days ago

    I am immune to everything I never get sick

  • Real Laundry Sauce
    Real Laundry Sauce 14 days ago

    But are u immune to the gae?

  • The Egg
    The Egg 14 days ago

    That rose thorn holy moly!

  • Fernando Limon
    Fernando Limon 14 days ago

    The one with one eye patch looks like adolf hitler........

  • Domi B
    Domi B 14 days ago

    So if I were to donate bone marrow, would that temporarily increase my likelihood to get sick? And if so, how much?

  • Madhan Raj
    Madhan Raj 14 days ago

    2:07 Skadoosh Wuxi finger hold

  • Pally Crawler
    Pally Crawler 14 days ago

    I think i am. I never get sick, plus i heal really quickly. I closed up a gash in my shin from a hatchet in 3 days. Also broke my foot in two places and never saw a doctor. I am super human... My immune system is crazy strong....

  • AnonymousStranger YouDon'tKnowMe

    I wonder if a person got subjected to a flu worst case scenario and survived, then his descendant gets the same thing, then the descendant's offspring, then so on, would they're cells carry the same genetic bluprint to create a Super Anti-Flu Cell (designed specifically to fight the flu and future adaptations of it)? Could that be possible? If yes, Virologist, or Vaccinologist (or whatever) work on that now.

  • MadMedic
    MadMedic 14 days ago

    I was seriously astonished on how deep you went in this video! Somatic recombination? That's not even taught in German High Schools. It makes me happy to see you guys spread some science to fight misconceptions on the immune system.

  • danny quach
    danny quach 14 days ago

    I swear I thought I finished AP Bio... this class has come to haunt me again

  • Money Money
    Money Money 14 days ago

    Check out my music video Titusville

  • Tushar Sharma
    Tushar Sharma 14 days ago

    is there anyone immune to HIV lol

  • Gamerlana
    Gamerlana 14 days ago

    You forgot to mention the cell mediated adaptive response, the T lymphocytes (CD8+ or CD4+), not to mention antigen presenting cells with MHC class 1 or 2 complexes that work in combination with them. B lymphocytes is the humoral adaptive response side of the adaptive immune system. There are just far too many intricacies this video skips over entirely.

  • 2012XF3
    2012XF3 14 days ago

    1:58 More like your bodys Avengers.